The Best Female-Lead Comedy TV Shows of the 21st Century
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- CreatorDavid E. KelleyStarsCalista FlockhartGreg GermannJane KrakowskiFollows the personal and professional life of lawyer Ally.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorStephen ColbertPaul DinelloMitch RouseStarsAmy SedarisPaul DinelloStephen ColbertA 46-year-old ex-drug addict returns to high school as a freshman.
- CreatorAmy Sherman-PalladinoStarsLauren GrahamAlexis BledelKeiko AgenaA dramedy centering around the relationship between a thirtysomething single mother and her teen daughter living in Stars Hollow, Connecticut.
- CreatorAllison M. GibsonStarsReba McEntireJoAnna Garcia SwisherSteve HoweyReba McEntire stars as the titular character in this smash sitcom about a single mom of three, navigating life in a Houston suburb.
- CreatorBryan FullerStarsEllen MuthCallum BlueJasmine GuyAfter being hit on the head by a toilet seat that fell from Mir space station, a young temp clerk becomes a grim reaper in death.
- CreatorBryan FullerTodd HollandStarsCaroline DhavernasKatie FinneranTyron Leitso24-year-old loner B.A. Jaye lives in a trailer park and sells souvenirs in Niagara Falls. Animal figurines and dolls speak to her and force her to interact with people and try to help them.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorMichael Patrick KingLisa KudrowStarsLisa KudrowLance BarberRobert Michael MorrisAn ex A-list celebrity attempts to rekindle the flame of her once prominent acting career with nothing but a camera crew and some determination.
- CreatorJenji KohanStarsMary-Louise ParkerHunter ParrishAlexander GouldWhen a suburban mother turns to dealing marijuana in order to maintain her privileged lifestyle after her husband dies, she finds out just how addicted her entire neighborhood already is.
- CreatorTina FeyStarsTina FeyAlec BaldwinTracy MorganLiz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.
- CreatorChris AlberghiniMike ChesslerTori SpellingStarsTori SpellingZachary QuintoJames CarpinelloA parody of the life of Tori Spelling, by Tori Spelling.
- CreatorFernando GaitánSilvio HortaStarsAmerica FerreraEric MabiusTony PlanaSmart but wholesome Betty embraces her unique appearance and independent attitude in the cutthroat world of New York fashion.
- CreatorCecelia AhernDonald ToddStarsChristina ApplegateJennifer EspositoKevin DunnA woman suffers from amnesia and is forced to find out who she really is.
- CreatorDan HarmonRob SchrabSarah SilvermanStarsSarah SilvermanLaura SilvermanBrian PosehnSarah's immature, only thinks of herself and has no inhibition nor work. Her sister Laura pays her rent. She has a gay couple as neighbors. Laura's seeing cop Jay.
- CreatorGreg DanielsMichael SchurStarsAmy PoehlerJim O'HeirNick OffermanThe absurd antics of an Indiana town's public officials as they pursue sundry projects to make their city a better place.
- CreatorLiz BrixiusEvan DunskyLinda WallemStarsEdie FalcoMerritt WeverPaul SchulzeA drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorDiablo CodyStarsToni ColletteJohn CorbettRosemarie DeWittA woman struggles to find a balance between her dissociative identity disorder and raising a dysfunctional family.
- CreatorJosh BermanStarsBrooke ElliottMargaret ChoKate LeveringA vapid aspiring model killed in a car crash gets brought back to life as an intelligent, overweight lawyer, hoping to find the meaning of inner beauty.
- CreatorDarlene HuntStarsLaura LinneyOliver PlattGabriel BassoA suburban mother faces her cancer diagnosis while trying to find humor and happiness as well.
- CreatorLauren IungerichStarsAshley RickardsBeau MirchoffJillian Rose ReedAn unpopular 15-year-old gains immediate, yet unwanted, popularity at her high school when the student body mistakes an accident she has for a suicide attempt.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorWhitney CummingsMichael Patrick KingStarsKat DenningsBeth BehrsGarrett MorrisTwo young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- CreatorLaura DernMike WhiteStarsLaura DernDiane LaddSarah BurnsA self-destructive woman who has a spiritual awakening becomes determined to live an enlightened life, creating havoc at home and work.