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- As medical advances cure patients with cancer, who a decade ago may not have survived, doctors face the challenge of using newer therapies which are not without risk.
- As medical advances save children who a decade ago may not have survived, Alder Hey Children's Hospital faces the challenge of providing ongoing care for these complex patients.
- With NHS 'bed blocking' numbers at their highest level since 2017, Liverpool's hospitals are struggling to discharge patients because of a lack of care in the community.
- Alder Hey Children's Hospital is home to a world-renowned craniofacial department, one of only 4 in the UK treating life-threatening congenital skull and facial abnormalities.
- The 4th series charts life at 6 NHS Trusts across one city. Royal Liverpool University Hospital staff face an emergency as two floors of the building are flooded. At Alder Hay Children's Hospital 3-year-old Charlie has a brain tumour.
- A teenager self-funds cutting-edge surgery for his cerebral palsy. Surgeons go to appeal to fund an 81-year-old's surgery and use new DNA tumour profiling to try to save a baby.
- Alder Hay closes its critical care unit to new admissions meaning that the surgical team cannot go ahead with any operations. A 5-year-old child returns 3 times for her cancelled heart operation.
- A consultant recruitment crisis threatens care at Liverpool Women's Hospital. The treatment of a pregnant woman is complicated because she has cancer. A 64-year-old woman has a tumour removed from her womb.